16TH INTERNATIONAL RESEARCH SCHOOL
Screening of compounds in an in vitro model of lipotoxic liver cell damage
Medical biotechnology
How do liver cells respond to excess lipids, and can they be protected from damage? In this project, the participants will establish an in vitro model of lipotoxicity using hepatocyte-like cells and perform screening of various substances that can modify the cellular response to lipid overload.
HepG2-cell line under a microscope
Students will learn fundamental cell biology techniques, including cell culture, aseptic work, and experimental design. The effects of tested compounds on cell viability and lipid accumulation will be evaluated using microscopy and quantitative assays. The final outcome will be a collaborative study demonstrating differences in the biological activity of tested substances.
Incubation of human somatic cell culture
Requirements for participants:
Students aged 14-18 with knowledge of the school curriculum in general biology, genetics, and cytology are invited to participate. Relevant topics include cell structure, gene expression, cell research methods, types of microscopy, and principles of cell culture.
Students aged 14-18 with knowledge of the school curriculum in general biology, genetics, and cytology are invited to participate. Relevant topics include cell structure, gene expression, cell research methods, types of microscopy, and principles of cell culture.
Tutors
Ivan Troev
Yakutsk, Russia
Yakutsk, Russia
Ivan is a biotechnology researcher specializing in medical biotechnology. He works at M.K. Ammosov North-Eastern Federal University, focusing on cell biology, regenerative medicine, and experimental models of metabolic disorders. His research interests include cellular mechanisms of tissue damage, in vitro disease modeling, and screening of biologically active compounds with cytoprotective properties. He is involved in the development of biomedical technologies and educational projects aimed at engaging school students in research activities.
Denis Sivtsev
Yakutsk, Russia
Yakutsk, Russia
Denis is a research assistant at the Medical Biotechnology Laboratory at the Medical Institute and a student in the Chemistry Department at the Institute of Natural Sciences of the M.K. Ammosov North-Eastern Federal University. His research interests include colloid chemistry, medical polymers, biotech product formulations, and pharmacology. He is a co-author of three patents and seven scientific articles.
