Hello everyone,
We continue our series of IRSchool project presentations, and today we are pleased to introduce a project in medical biotechnology titled "Screening of compounds in an in vitro model of lipotoxic liver cell damage."
The project addresses a key question: how do liver cells respond to excess lipids, and can they be protected from the resulting damage? Participants will establish an in vitro model of lipotoxicity using hepatocyte-like cells and screen a range of compounds for their ability to influence cellular responses to lipid overload.
Throughout the project, students will gain practical experience in essential cell biology techniques, including cell culture, aseptic work, and experimental design. The effects of the tested compounds on cell viability and lipid accumulation will be evaluated using microscopy and quantitative assays. The final deliverable will be a collaborative study highlighting differences in biological activity among the compounds.
Guiding the project are two accomplished tutors. Ivan Troev is a researcher at M.K. Ammosov North-Eastern Federal University, specialising in medical biotechnology, cell biology, regenerative medicine, and experimental models of metabolic disorders. Denis Sivtsev is a research assistant at the Medical Biotechnology Laboratory of the Medical Institute and a student in the Chemistry Department at the Institute of Natural Sciences of the same university.
If you are interested, find out more on the project page
https://irschool.org/project_medbiotech2026